There are only a few times in life when you get to live through a revolution. For many of us, this is our third: first the internet, then mobile, now AI Superintelligence. In moments of foundational change, the winning mindset isn’t to optimize – it’s to reimagine.
This era of AI Superintelligence rewards founders who are willing to think in paradigms, not features. The ones who understand that technology adoption can feel slow until, suddenly, it isn’t.
The AI Disruptors 60 list, a new honoree list curated by Greenfield Partners and unveiled live at TechCrunch Disrupt, spotlights 60 standout companies redefining what’s possible with AI. These are the builders creating the infrastructure powering AI’s adoption, and the visionaries applying it to transform industries from manufacturing to pharmaceuticals, logistics to law. Collectively, they reveal an inflection point: AI is becoming the default way modern systems operate. The founders behind these companies aren’t chasing headlines but are truly rebuilding the economic backbone of entire industries.
Together, this year’s winners have raised nearly $3 billion. Stemming from across the globe, this young group of innovators, the majority of which were founded less than 3 years ago, is a testament to how fast this new wave is unfolding.
Innovation rarely announces itself. It shows up in the form of teams quietly rewriting how the world works. The AI Disruptors 60 recognizes those teams that are building what will soon power everything else.
Alongside this year’s honorees, we’re celebrating the pioneers who defined AI at its dawn, companies like Anthropic, OpenAI, VAST Data, Harvey, Lovable and Mercor. Their early breakthroughs set the standard for what intelligent systems can achieve and paved the way for the next generation, now building on their momentum.
The AI Disruptors 60 is a compass: the startups to watch, invest in, and partner with as AI becomes foundational.
The full list:
AAl is a team of elite researchers spanning computer science, mathematics, physics, and biology. We are building transformative Al technology that drives new scientific discoveries and reshapes how humanity solves its hardest problems. Our mission is simple: to usher in a new age of discovery by cracking the code of superintelligence.
Adaptive ML develops an RLOps platform enabling companies to test, serve, and adapt more performant & cost-efficient large language models.
At Anam, we’re building the next interface for technology, AI personas indistinguishable from real life. Founded by Caoimhe and Ben after leaving Synthesia, Anam is redefining how humans interact with technology so it feels as natural and human as conversation.
Assort Health is the most comprehensive patient experience platform powered by specialty-specific, agentic AI, omnichannel, and EHR/PMS-integrated, proven to eliminate hold times and achieve up to 94%+ PSAT and 98% resolution across >40M patient interactions.
Basis is an AI platform for accounting firms, providing accountants with a team of AI agents that understand accounting, learn specific client needs, work independently, and take real actions. Accounting teams integrate Basis as part of their team, delegating core workflows and automating time-consuming, manual work. Basis is already deployed in many of the country’s largest accounting firms.
Braintrust is the agent observability platform that helps teams build quality AI products. It connects evals, observability, and iteration in one workflow for both engineers and PMs. Teams like Notion, Stripe, Zapier, Vercel, and Ramp use Braintrust to catch regressions before users do, compare prompts and models side by side, and improve AI features with every release.
Browserbase is a cloud browser automation platform for hosting, managing, and monitoring headless browsers for web automation. Browserbase powers web browsing capabilities for AI agents & applications. Our globally scalable and secure infrastructure allows AI companies to navigate, interact with, and automate tasks on websites, reliably.
Cartesia is building the next generation of AI: ubiquitous, interactive intelligence that runs anywhere. Founded by Stanford AI Lab PhDs who invented State Space Models, Cartesia pairs deep research with product design to ship cutting-edge models like Sonic (ultra-realistic text-to-speech) and Ink (fast, low-cost speech-to-text). Its newest product, Line, enables fully customizable, code-first voice agents.
CodeRabbit is the pioneer of AI Code Reviews, helping software developers ship code faster and with fewer bugs. CodeRabbit’s purpose-built context engineering approach integrates with foundational LLMs to automate code reviews, fix critical bugs that are often hard to find, and free up developers from lengthy review cycles. With CodeRabbit you can cut review time and bugs in half, instantly.
Cogent is an AI-native cybersecurity platform transforming vulnerability management. Its autonomous agents continuously identify, prioritize, and remediate cybersecurity risks, preventing breaches and driving efficiency across organizations. Founded by leaders from Abnormal Security, Coinbase, and other top companies, Cogent supercharges cybersecurity for the world’s leading enterprises and brands across industries.
Cogna builds AI-powered applications tailored to critical industries. The Cogna platform generates custom tools directly from customer process descriptions and integrates directly with their existing systems, providing the perfect AI-assisted control centers for specialist high-value knowledge work. We work on the most important challenges in operations, procurement, asset management and compliance. The result is software that fuses complex data, optimises decisions, and delivers real-world savings often in the millions of dollars, in just weeks.
Console is redefining IT operations. It serves as the AI execution layer for modern enterprises, automating repetitive IT tickets like password resets and laptop unlocks so teams can focus on impactful work. Console integrates with systems like Slack, Okta, and Jira, acting as the team’s first line of defense.
Converge Bio is pioneering the next era of drug discovery by uniting generative AI with biological systems. Its platform, Converge Lab, uses curated multimodal data to design novel molecules, predict their behavior, and uncover disease mechanisms.
CuspAI’s AI-powered ‘search engine’ for materials blends generative models with chemistry simulators to discover new materials faster. It shortens discovery timelines from decades to months by predicting and optimizing material properties across billions of combinations.
Darwin helps government agencies adopt AI securely. Its “Darwin Govern” platform centralizes AI governance, enforcing guardrails and restoring trust, while “Launchpad” builds AI workflows tailored to public administration.
Decart is redefining the boundaries of what generative AI can achieve in both infrastructure and user-facing applications. Founded in late 2023 and backed by Benchmark, Sequoia, and Zeev Ventures, Decart’s mission is to build efficient, vertically integrated AI systems that enable real-time, interactive experiences at scale. In under a year, the company raised $153 million and reached a $3.1 billion valuation, highlighting both rapid momentum and market conviction in its vision. At the infrastructure level, Decart created a proprietary training and inference engine that reduces compute costs from an industry norm of $100 per hour to just $0.25.
DustPhotonics designs and manufactures high-speed optical communication solutions for data centers, high performance computing and enterprise networks, offering a new standard to optimize high volume data center connectivity, performance and reliability, and best in class alignment.
Dyna Robotics is building embodied AI foundation models through real-world deployment at scale. Its robots perform complex manipulation tasks, such as folding, packaging, warehouse kitting, and food preparation, by learning incrementally in production environments. The DYNA-1 system, launched in 2024, was the first embodied foundation model deployed commercially, combining product performance with data generation for continuous improvement.
Eleos is the leading AI platform for behavioral health, substance use disorder, home health, and hospice. Its provider-focused technology streamlines documentation, simplifies revenue cycle management, and surfaces care insights to drive better outcomes. Eleos’ AI tools reduce documentation time by more than 70%, double client engagement, and improve symptom reduction by 3–4x.
Emerald AI enables AI data centers to flexibly adjust power consumption on demand. Its platform orchestrates AI compute loads across a network of data centers, creating “AI Virtual Power Plants” that transform data centers from grid liabilities to energy assets.
Emerix optimizes and automates supply chains so companies can focus on innovation and customers. Its AI agents monitor, alert, and act in real time to prevent costly errors and delays. Emerix empowers teams with predictive insights, automated exception handling, and collaboration tools.
Eve is an AI platform for plaintiff law firms. It captures institutional knowledge and applies it across case management, enabling firms to handle up to 2.5 times more cases without expanding attorney headcount. Eve returns an average of 20 hours per week per lawyer, generating legal drafts and medical chronologies in minutes.
Exodigo provides underground intelligence for construction and infrastructure projects using non-intrusive multi-sensor scanning and AI to create accurate 3D subsurface maps. Its mission is to eliminate costly surprises that cause $100 billion in annual project delays and damages.
Fable Security redefines human risk management. While over 60% of breaches involve human error, traditional training fails to change behavior. Fable’s human risk platform directly shapes employee behavior through adaptive, AI-driven behavioral reinforcement.
Firsthand built the first AI-powered Brand Agent platform, transforming how companies engage consumers through brand-owned AI agents. These agents deliver expertise in real time, adapting to user interests and driving action. Unlike AI tools built for efficiency, the Firsthand Brand Agent Platform™ powers front-line engagement and shapes the consumer experience. Its AI-native system, Lakebed™, ensures brands retain full control of their data and content.
Flexion builds the AI software stack that makes humanoid robots move fluidly, act autonomously, and adapt to real-world complexity. Its deep reinforcement learning and sim-to-real capabilities enable scalable humanoid robotics for safe, efficient, human-like operation.
FLORA is a creative tool with every single creative AI model across text, image & video on one infinite canvas. You can connect these models together to rapidly concept creative ideas and build creative workflows.
GoodShip is the first all-in-one platform for freight orchestration and procurement. It brings AI-powered insights to optimize transportation spend and service in real time, helping major brands save millions and reduce late loads.
Gradient Labs builds conversational AI for financial services, automating customer operations while maintaining compliance. Designed for regulated industries, its platform handles everything from support queries to back-office tasks.
HappyRobot is building the AI-native operating system for the real economy. It connects intelligence and execution to optimize supply chains and industrial operations. Its system acts as an autonomous AI workforce guided by orchestrating intelligence.
Founded in 2023, Harmonic is an artificial intelligence company backed by Robinhood CEO Vlad Tenev and led by CEO Tudor Achim. It is developing Mathematical Superintelligence (MSI), the next generation of artificial intelligence which is rooted in mathematics and which guarantees accuracy and eliminates hallucinations. Harmonic’s IMO Gold Medal model, Aristotle, is being used by researchers across the world to tackle open problems in mathematics, science, and beyond.
Legora’s collaborative AI platform helps lawyers review and research faster, draft smarter, and advise with precision. Backed by ICONIQ, Benchmark, General Catalyst, and Redpoint, it serves more than 400 firms in over 40 markets.
Letta, created by the researchers behind MemGPT, introduces “sleeptime compute,” where subconscious agents operate continuously in the background. This allows AI models to think persistently and deliver more accurate, scalable results.
LlamaIndex enables developers to build AI agents that extract insights and act on enterprise documents. Its open-source framework has over 4M downloads per month and powers more than 200M document processes on LlamaCloud.
Ludeo turns passive gaming content into interactive, playable moments. It converts video clips into instant “click-and-play” experiences, bridging watching and playing. Led by gaming veterans, Ludeo’s AI-native engine is already live with top publishers.
Lumafield is transforming manufacturing with AI-powered industrial CT scanning, making high-resolution, non-destructive inspection accessible to businesses of all sizes. Its Neptune lab scanner and Triton production platform are redefining product development and quality control across industries from electronics and athletic equipment to consumer packaged goods and aerospace. Powered by Voyager, Lumafield’s cloud-native software suite, and Atlas, its generative AI engine, the company delivers manufacturers unprecedented insight and automation. Backed by more than $150M from top investors, Lumafield is pioneering Software-Defined Inspection, combining 3D X-ray CT technology and AI-driven analysis—to unlock speed, precision, and innovation in a $16T manufacturing market.
Maven helps businesses scale exceptional customer experiences. Build AI agents yourself or have us build them for you. Think of it as your smart operating system that connects your tools, streamlines workflows, and delivers consistent experiences wherever customers engage. Our agents are accurate and effective, and they are certified to ISO 27001 and SOC 2 Type II, with HIPAA-compliant deployments available. They learn your business, plug into your existing tech, and improve over time.
Meticulous creates and maintains end-to-end software tests with zero developer effort, accelerating software delivery. Used by Wiz, Dropbox, and Notion, it eliminates debugging, reduces maintenance, and ensures reliability.
Motif brings generational change to building design through AI-native, cloud-first tools that redefine collaboration and intelligence flow. It replaces outdated AEC software, offering precision 3D design comparable to Figma or Cursor for real-world construction.
Netic is the autonomous AI revenue engine for essential services industries like HVAC, plumbing, and electrical. It has booked over 50,000 jobs worth millions for customers like Hoffmann Brothers and Heartland, led by former Scale AI executive Melisa Tokmak.
Nexos.ai unifies access to 200+ LLMs and specialized models through one secure API and workspace. Founded by Nord Security’s co-founders, it raised $8M led by Index Ventures. Nexos streamlines enterprise AI adoption with deep governance and cost control.
Nexthop AI is a cohesive team of seasoned industry experts leading disruptive technical innovation in AI and Cloud networking through collaborative product design, system architecture, and network engineering capabilities. It specializes in building highly efficient custom scale-up and scale-out and DCI solutions for hyperscalers. These integrate seamlessly into their optimized cloud stack and include networking hardware designed to each customer’s specifications, a network operating system of their choice hardened by Nexthop AI, and pre-tested optical and electrical interconnects from the customer’s diverse supply chain.
Notch delivers secure, fully managed AI agents that automate routine customer support and back-office workflows, from account updates and information requests to internal operations tasks. We replicate your top-performing agents, fully aligned with your policies, workflows, and tone of voice. Notch is not a chatbot or a toolkit, we handle implementation end-to-end and operate as an extension of your team, not a replacement.
Omnea modernizes procurement with Omnea AI, a suite of copilots that turns procurement from a manual process into an intelligent partner. It automates supplier requests, analyses contracts, and summarizes due diligence, reducing complexity and waste.
OpenRouter is an open platform routing to 400+ LLMs across 60+ providers. It enables developers to compare, switch, and integrate models easily while avoiding vendor lock-in, driving openness in the AI ecosystem.
Paid is building AI agents that run entire workflows for operations teams, from vendor onboarding to approvals to compliance. Instead of just suggesting next steps, Paid’s agent takes action, handling routine processes that eat up time and headcount. It integrates across tools, keeps humans in the loop when needed, and helps companies scale without scaling overhead. This is operations, automated.
PhaseV improves clinical trial outcomes using multi-modal AI/ML to enhance patient targeting and trial design. Based in Boston, it integrates generative and causal AI to reduce failures and accelerate drug development.
Plenful eliminates administrative bottlenecks in healthcare, automating manual back-office work. It targets operational inefficiency, which consumes 25% of U.S. healthcare spending, with AI workflows that streamline authorizations and reimbursements.
Profound is the category-defining AI Visibility platform that helps brands control their presence in AI responses. Used by the best marketers in the world from companies like like Ramp, Clay, MongoDB and Statsig, Profound is leading the way in this new category. Profound recently closed a $35M Series A led by Sequoia Capital with participation from Kleiner Perkins and Khosla Ventures.
Qodo’s mission is to end the speed vs. quality tradeoff in enterprise AI software development by making sure every code change, human or AI, meets production standards. The Qodo AI Code Review platform protects long-term code integrity across the SDLC, bringing deep, customer-specific context to every PR. It understands your architecture, history, and best practices, producing accurate, actionable, and consistent reviews. When issues surface, Qodo goes beyond comments with intelligent remediation: ready-to-apply fixes, test updates, and cross-service impact analysis. The result is faster merges and a standardized, enforceable quality bar across teams so enterprises move quickly while shipping production-ready software with confidence.
Rillet rebuilds enterprise accounting for scale and efficiency. After raising $70M led by Andreessen Horowitz and ICONIQ, Rillet signed 200+ customers and partners like Armanino and Wiss, cutting close times to days.
Founded in 2020 out of the Technical University of Munich, RobCo is on a mission to make industrial automation more accessible, affordable, and adaptable. Its patented modular hardware kit, combined with the RobCo Studio no-code software platform, allows industrial companies of all sizes to automate repetitive and dangerous tasks quickly and with unmatched flexibility. Whether it’s machine tending, palletizing, dispensing, or welding, RobCo’s modular robot kits provide versatile end-to-end solutions that are simple to deploy and manage remotely – without heavy upfront investment or specialist expertise. With offices in Munich and San Francisco and robots already in operation worldwide, RobCo is supercharging a new generation of industrial companies to reduce costs, boost productivity, and compete on a global stage.
Sett builds Agentic AI to transform game development and marketing, starting with creative testing for mobile games. Its platform generates and optimizes playable ads, tackling creative fatigue and scaling performance.
Spacial AI automates construction permitting, reducing delays and costs while empowering teams to focus on design. Built by AEC veterans, its platform simplifies approvals and redlines through intelligent automation.
Synthflow AI powers enterprise-scale voice AI, enabling teams to automate and improve customer conversations. Its AI handles millions of calls monthly, blending human purpose with voice automation flexibility.
Tennr automates referral workflows in healthcare, connecting primary and specialty care. Its orchestration platform eliminates manual fax-based systems, helping providers convert more patients and reduce denials.
Tessl pioneers Spec-Driven Development (SDD), where intent written in natural language becomes executable specs for AI agents. It merges AI speed with production reliability, making software building faster and safer.
Torq Hyperautomation unifies and automates entire security infrastructures. It integrates detection and remediation workflows, freeing security teams from manual management and improving protection at scale.
Traversal reduces downtime costs by automating incident troubleshooting. With AI-driven root cause analysis, it helps engineers resolve production issues faster, turning hours of firefighting into minutes of insight.
Vega is on a mission to deliver full detection coverage over complete, distributed data. Our AI-native Security Analytics Mesh connects instantly to all your sources—cloud, object storage, EDR, and even your current SIEM, without requiring data to move or centralize. Vega runs analytics directly where data lives, unifying detection and investigation while cutting out the SIEM tax. The result is faster incident response, complete visibility, and an AI-powered foundation for the modern SOC.
